Preheat the oven to 400°F.Line a baking sheet with parchment paper or foil.
Pat the salmon fillets dry with paper towels. Drizzle with olive oil. Season both sides with salt, pepper, and garlic powder. Place on the prepared baking sheet.
Bake the salmon for 10–12 minutes, or until the internal temperature reaches 125–130°F for medium or 140°F for fully cooked.
While the salmon bakes, combine soy sauce, hot honey, oyster sauce, and cayenne pepper in a small bowl. Stir until well blended.
Once the salmon is cooked, spoon the sauce over the fillets and brush to coat evenly. Turn on the broiler and broil for 1 minute, just until the glaze bubbles and caramelizes slightly.
Plate and enjoy immediately. Great with rice, steamed veggies, or a crisp salad.