In a bowl, combine the ground beef with the salt, paprika, garlic powder, and onion powder. Mix until well combined.
Evenly spread a thin layer of the seasoned beef over each tortilla.
Heat a lightly oiled skillet over medium heat.
Place the tortilla beef-side down in the skillet and cook until the beef is browned.
Flip the tortilla over and top with an American cheese slice.
Cover the skillet with a lid for 30–60 seconds, or until the cheese is melted.
Continue cooking until the tortilla is golden and crispy.
Remove from the skillet and let cool on a wire rack to keep the tortilla crisp.
Meanwhile, make the Big Mac sauce by mixing the Greek yogurt, mayonnaise, ketchup, mustard, chopped pickles, and onion powder until smooth.
Spread the Big Mac sauce over each taco, then top with diced onions and extra pickle slices.
Serve immediately and enjoy!